1,761 การเปรียบเทียบการใช้ยากลุ่ม Beta-blocker ที่ให้ทางหลอดเลือดดำ

ที่โรงพยายบาลมียา Beta-blocker ที่สามารถ ให้ทางหลอดเลือดดำอยู่ 1 ตัว จึงลองสืบค้นข้อมูลเรื่องข้อบ่งชี้ ขยาดยา และรายละเอียดของยาเพิ่ม พบดังนี้ครับ

ตารางแสดงการเปรียบเทียบยากลุ่ม Beta-blocker ที่ให้ทางหลอดเลือดดำ

Agent	FDA-Approved Indication(s) for Intravenous Administration*	Intravenous Dose Recommendations (Adult)	Comments
Atenolol (Tenormin®)	- Acute myocardial infarction	5 mg IV bolus over 5 minutes, followed by a second IV bolus 10 minutes later	§  Beta-1 selective §  Maximum IV bolus dose = 10 mg
Esmolol (Brevibloc®)	-  Hypertension, intra-operative or - Tachyarrhythmia, intra-operative	80 mg IV bolus (» 1 mg/kg) over 30 seconds, generally followed by continuous infusion	§  Beta-1 selective §  Short-acting (t1/2 » 9 minutes) §  May be used as a continuous infusion §  When used for acute myocardial infarction, dosing is generally the same as listed for supraventricular arrhythmia §  Maximum continuous infusion rate = 200 mcg/kg/minuteจ
	-  Hypertension, post-operative or  -  Tachyarrhythmia, post-operative	500 mcg/kg IV bolus over 1 minute, generally followed by continuous infusion or oral maintenance dose
	-  Supraventricular arrhythmia	500 mcg/kg IV bolus over 1 minute, generally followed by continuous infusion or oral maintenance dose
Labetalol (Trandate®)	-  Hypertension	20 mg IV bolus over 2 minutes (may repeat injections of 20-80 mg at 10 minute intervals) Maximum total dose = 300 mg	§  Nonselective beta-adrenergic blocker with selective alpha-adrenergic blockade §  May be used as a continuous infusion
Metoprolol (Lopressor®)	-  Acute myocardial infarction	5 mg IV bolus every 2 minutes x 3 (total dose = 15 mg)	§  Beta-1 selective §  May be used as a continuous infusion
	-  Cardiac dysrhythmia	2.5 - 5 mg IV bolus over 2 minutes, may repeat to total of 3 doses (higher doses may be necessary)
Propranolol (Inderal®)	-   Acute myocardial infarction	0.1 mg/kg divided into 3 equal doses given at 2-3 minute intervals (rate not to exceed 1 mg/min)	§  Nonselective beta-adrenergic blocker §  Administration rate should not exceed 1 mg/minute §  Initial dose may be repeated in 2 minutes, but additional doses should not be administered until 4 hours later §  Most references suggest continuous EKG monitoring when IV propranolol is administered
	-  Cardiac dysrhythmia	0.5 - 3  mg IV bolus (rate not to exceed 1 mg/min) Or 0.1 mg/kg divided into 3 equal doses given at 2-3 minute intervals
	- Thyroid storm, rapid control	1 mg/min IV bolus (maximum dose = 10 mg).  May repeat in 4 - 6 hours

 Ref: doctors.seton.net Link of reference